J Clin Gastroenterol 2019 01;53(1):76-77
Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran.
Hepatol Int 2021 May 6. Epub 2021 May 6.
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.
Background/purpose: Imaging diagnosis of hepatocellular carcinoma (HCC) is important, but the diagnostic performance of combined computed tomography (CT) and magnetic resonance imaging (MRI) using the Liver Imaging Reporting and Data System (LI-RADS) v2018 is not fully understood. We evaluated the clinical usefulness of combined CT and MRI for diagnosing HCC ≤ 3.0 cm using LI-RADS. Read More
Case Rep Endocrinol 2021 14;2021:5584198. Epub 2021 Apr 14.
Division of Endocrinology and Metabolism, Japanese Red Cross Musashino Hospital, Tokyo, Japan.
Background: Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. ACCs often secrete adrenal steroid hormones including cortisol and androgens; however, aldosterone-producing ACC is very rare. Although adrenal production of aldosterone is assessed by adrenal venous sampling, the use of sampling from the relevant vein to assess aldosterone production from a tumor arising from ACC metastasis has not been previously reported. Read More
Drug Metab Dispos 2021 May 5. Epub 2021 May 5.
Novartis Institute for Biomedical Research, East Hanover, United States, United States.
Tropifexor (NVP-LJN452) is a highly potent, selective, non-steroidal, non-bile acid farnesoid X receptor (FXR) agonist for the treatment of nonalcoholic steatohepatitis (NASH). Its absorption, metabolism, and excretion were studied following a 1-mg oral dose of [C]tropifexor to four healthy male subjects. Mass balance was achieved with ~94% of the administered dose recovered in excreta through 312 hours collection period. Read More
Xenobiotica 2021 May 6:1-36. Epub 2021 May 6.
Institute of Chinese Materia Medica, Henan Provincial Academy of Traditional Chinese Medicine, Zhengzhou, China.
Diabetes mellitus is a chronic metabolic disorder with multiple complications, patients who receive metformin may have a simultaneous intake of herbal medicine containing rutaecarpine due to cardiovascular protection and hypolipidemic effects of rutaecarpine. There might be drug interactions between metformin and rutaecarpine. This study aimed to investigate the effects of rutaecarpine on the pharmacodynamics and pharmacokinetics of metformin in diabetic rats. Read More
Acta Radiol 2021 May 5:2841851211014192. Epub 2021 May 5.
Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
Background: In patients with bilobar metastatic liver disease, surgical clearance of both liver lobes may be achieved through multiple-stage liver resections. For patients with extensive disease, a major two-staged hepatectomy consisting of resection of liver segments II and III before right-sided portal vein embolization (PVE) and resection of segments V-VIII may be performed, leaving only segments IV ± I as the liver remnant.Purpose: To describe the outcome following right-sided PVE after prior complete resection of liver segments II and III. Read More