A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors.

Cytokine 2017 02 16;90:96-99. Epub 2016 Nov 16.

Laboratory of Innate Immunity, Centre Hospitalier Universitaire (CHU) Ste-Justine Research Center/Department of Microbiology, Infectiology & Immunology, University of Montreal, Montreal, Quebec, Canada. Electronic address:

An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.

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http://dx.doi.org/10.1016/j.cyto.2016.10.018DOI Listing
February 2017
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