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Drug Discov Today 2022 May 16. Epub 2022 May 16.

Department of Urological Sciences, Vancouver, BC, V6H3Z6, Canada; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, V6H3Z6, Canada. Electronic address:

Long noncoding RNAs (lncRNAs) are RNA molecules involved in gene regulation at transcriptional, post-transcriptional, and epigenetic levels. lncRNAs participate in regulating apoptosis and autophagy in pancreatic cancer (PCa) and can promote and/or decrease the proliferation rate of tumor cells. The metastasis of PCa cells is tightly regulated by lncRNAs and they can affect the mechanism of epithelial-mesenchymal transition (EMT) to modulate metastasis. Read More

Lancet Diabetes Endocrinol 2022 May 16. Epub 2022 May 16.

Department of Surgery, University of Alberta, Edmonton, AB, Canada; Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. Electronic address:

Background: Islet transplantation offers an effective treatment for selected people with type 1 diabetes and intractable hypoglycaemia. Long-term experience, however, remains limited. We report outcomes from a single-centre cohort up to 20 years after islet transplantation. Read More

Dig Dis 2022 May 19. Epub 2022 May 19.

Background: Neuroendocrine neoplasms of the ampulla of Vater (ampullary NEN) have features of both gastrointestinal and pancreato-biliary (PB) NEN. However, the limited number of studies examining ampullary NEN makes it difficult to clarify their unique characteristics. This study aimed to elucidate the clinical characteristics of ampullary NEN. Read More

Clinics (Sao Paulo) 2022 May 16;77:100044. Epub 2022 May 16.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Hubei Province, China.

Background: Importin 7 (IPO7) belongs to the Importin β family and is implicated in the progression of diverse human malignancies. This work is performed to probe the role of IPO7 in pancreatic cancer development and its potential downstream mechanisms.

Methods: IPO7 expression in PC and paracancerous tissues were measured using Immunohistochemistry (IHC) staining and qRT-PCR. Read More

Rev Col Bras Cir 2022 27;49:e20223150. Epub 2022 Apr 27.

- AC Camargo Cancer Center - São Paulo - SP - Brasil.

Objective: the recommendations of the decisions made by the Tumor Board (TB) should be followed to identify barriers that may interfere with the execution of the previously decided, best care for the patient. The aim of this study is to assess whether the TB conduct decision was performed in patients with pancreatic tumors, their life status 90 days after the TB decision, and to analyze the reasons why the conduct was not performed.

Methods: we conducted a retrospective study with patients with pancreas tumors, evaluated between 2017 and 2019. Read More