Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.

Cell Rep 2016 11 3;17(9):2474-2487. Epub 2016 Nov 3.

Department of Laboratory Medicine, Laboratory for Medical Immunology, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands. Electronic address:

Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.

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http://dx.doi.org/10.1016/j.celrep.2016.10.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130901PMC
November 2016
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