Tumour Biol 2016 Nov 5. Epub 2016 Nov 5.
Department of Neurosurgery, Bou Ali Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Ann Transl Med 2021 Mar;9(6):505
Department of Interventional Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Background: The identification of the important elements that control hepatic stellate cell (HSC) activation will expand our understanding of the mechanism of liver fibrosis induced by hypoxia and affect the outcome of clinical treatment. A previous research demonstrated that N-Myc downstream-regulated gene 2 () is a potential regulator of fibrosis and a downstream target gene of hypoxia-inducible factor 1 (). In this research, we studied the expression and function of NDRG2 in liver fibrosis induced by hypoxia. Read More
J Gastrointest Oncol 2021 Feb;12(1):100-111
State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Background: Radiation-induced gastrointestinal syndrome (GIS) often occurs after therapeutic or accidental exposure to high doses of radiation. Unfortunately, there are still no effective medical treatments for GIS. N-Myc downstream regulated gene 2 (NDRG2), is a tumor suppressor gene and promotes cell apoptosis and differentiation. Read More
J Cell Mol Med 2021 Feb 9. Epub 2021 Feb 9.
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Renal cell carcinoma (RCC) is the most common form of kidney cancer, with a high recurrence rate and metastasis capacity. Circular RNAs (circRNAs) have been suggested to act as the critical regulator in several diseases. This study is designed to investigate the role of circCSNK1G3 on RCC progression. Read More
Front Genet 2020 15;11:596826. Epub 2021 Jan 15.
Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Prostate cancer (PCa) is occurred with increasing incidence and heterogeneous pathogenesis. Although clinical strategies are accumulated for PCa prevention, there is still a lack of sensitive biomarkers for the holistic management in PCa occurrence and progression. Based on systems biology and artificial intelligence, translational informatics provides new perspectives for PCa biomarker prioritization and carcinogenic survey. Read More
Front Genet 2020 4;11:594824. Epub 2020 Nov 4.
Department of Infectious Diseases, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, China.
Liver fibrosis resulting from chronic liver damage constitutes a major health care burden worldwide; however, no antifibrogenic agents are currently available. Our previous study reported that the small molecule NPLC0393 extracted from the herb exerts efficient antifibrotic effects both and . In this study, a TMT-based quantitative proteomic study using a carbon tetrachloride (CCl)-induced mouse model of liver fibrosis was performed to identify the potential target of NPLC0393. Read More