Iodine deficiency amongst pregnant women in South-West England.

Authors:
Prof Bijay Vaidya
Prof Bijay Vaidya
Royal Devon & Exeter Hospital and University of Exeter Medical School
Exeter | United Kingdom

Clin Endocrinol (Oxf) 2017 Mar 2;86(3):451-455. Epub 2016 Dec 2.

Department of Endocrinology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.

Introduction: Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West England.

Methods: Urine samples were obtained from 308 women participating in a study of breech presentation in late pregnancy. They had no known thyroid disease and a singleton pregnancy at 36-38 weeks' gestation. Samples were analysed for urinary iodine concentrations (UIC). Baseline data included age, parity, smoking status, ethnicity, body mass index (BMI) at booking, prenatal vitamin use and a dietary questionnaire. There was no difference in median UIC between women with (n = 156) or without (n = 152) a breech presentation (P = 0·3), so subsequent analyses were carried out as a combined group.

Results: Participants had a mean (SD) age 31(5) years, median (IQR) BMI 24·4 (22·0, 28·3) kg/m ; 42% were primiparous, 10% smoked during pregnancy, and 35% took iodine-containing vitamins. Ninety-six per cent were Caucasian. Median (IQR) UIC was 88·0 (54·3, 157·5) μg/l, which is consistent with iodine deficiency by WHO criteria. A total of 224/308 (73%) of women had UIC values <150 μg/l. Increasing milk intake was associated with higher UIC (P = 0·02). There was no difference in median (IQR) UIC between those women who took iodine-containing vitamins (n = 108) and those who did not (n = 200): 88 (54, 168) vs 88 (54, 150) μg/l, P = 0·7.

Conclusion: Iodine deficiency in pregnancy is common in South-West England. Measures to develop optimum prevention and treatment strategies are urgently needed.

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http://dx.doi.org/10.1111/cen.13268DOI Listing
March 2017
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(Supplied by CrossRef)
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Iodine nutrition in pregnancy and lactation
Leung et al.
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Prevalence of maternal dietary iodine insufficiency in the north east of England: implications for the fetus
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Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women
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