Age of onset of obesity and risk of type 2 diabetes.

Aust N Z J Public Health 2016 Dec 23;40(6):579-581. Epub 2016 Oct 23.

Baker IDI Heart and Diabetes Institute, Victoria.

Objective: To compare a simple measure - age of onset of obesity - to an obese-years construct (a product of duration and magnitude of obesity) as risk factors for type 2 diabetes.

Method: Participants from the Framingham Heart Study who were not obese and did not have diabetes at baseline were included (n=4,320). The Akaike Information Criterion (AIC) was computed to compare four Cox proportional hazards models with incident diabetes as the outcome and: (i) obese-years; (ii) age of onset of obesity; (iii) body mass index (BMI); and (iv) age of onset of obesity plus magnitude of BMI combined, as exposures.

Results: AIC indicated that the model with obese-years provided a more effective explanation of incidence of type 2 diabetes compared to the remaining three models. Models including age of onset of obesity plus BMI were not appreciably different from the model with BMI alone, except in those aged ≥60.

Conclusions: While obese-years was the optimal obesity construct to explain risk of type 2 diabetes, age of onset may be a useful, practical addition to current BMI in the elderly.

Implications: Where computation of obese-years is not possible or impractical, age of onset of obesity combined with BMI may provide a useful alternative.

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Source
http://dx.doi.org/10.1111/1753-6405.12593DOI Listing
December 2016
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