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    Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy.

    Ann Dermatol 2016 Oct 30;28(5):540-547. Epub 2016 Sep 30.
    Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
    Background: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF).

    Objective: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF.

    Methods: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution.

    Results: The patients were between 4 and 59 years of age. Four patients were older than 20 years of age. All of the patients had early-stage MF. In all patients, the atypical lymphocytic infiltrate had a perivascular distribution with epidermotropism. The CD4/CD8 ratio was <1 in 12 patients. Thirteen patients were treated with either narrowband ultraviolet B (NBUVB) or psoralen+ultraviolet A (PUVA), and all of them had complete responses.

    Conclusion: PL-like MF appears to have a favorable prognosis and occurrence of this variant in adults is uncommon. MF should be suspected in the case of a PL-like skin eruption. Therefore, biopsy is required to confirm the diagnosis of PL-like MF, and NBUVB is a clinically effective treatment.
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