Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy.

Authors:
Min Soo Jang
Min Soo Jang
Kosin University College of Medicine
Dong Young Kang
Dong Young Kang
Hannam University
Joon Hee Kim
Joon Hee Kim
Inje University Seoul Paik Hospital
Hark Rim
Hark Rim
Kosin University College of Medicine
Kee Suck Suh
Kee Suck Suh
Kosin University College of Medicine
South Korea

Ann Dermatol 2016 Oct 30;28(5):540-547. Epub 2016 Sep 30.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Background: Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF).

Objective: We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF.

Methods: This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution.

Results: The patients were between 4 and 59 years of age. Four patients were older than 20 years of age. All of the patients had early-stage MF. In all patients, the atypical lymphocytic infiltrate had a perivascular distribution with epidermotropism. The CD4/CD8 ratio was <1 in 12 patients. Thirteen patients were treated with either narrowband ultraviolet B (NBUVB) or psoralen+ultraviolet A (PUVA), and all of them had complete responses.

Conclusion: PL-like MF appears to have a favorable prognosis and occurrence of this variant in adults is uncommon. MF should be suspected in the case of a PL-like skin eruption. Therefore, biopsy is required to confirm the diagnosis of PL-like MF, and NBUVB is a clinically effective treatment.

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http://dx.doi.org/10.5021/ad.2016.28.5.540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064181PMC
October 2016
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