Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Authors:
Dan J Stein
Dan J Stein
University of Cape Town
South Africa
Gareth Barker
Gareth Barker
United Kingdom
Tulio Guadalupe Samuel R Mathias Theo G M vanErp Christopher D Whelan Marcel P Zwiers Yoshinari Abe Lucija Abramovic Ingrid Agartz Ole A Andreassen Alejandro Arias-Vásquez Benjamin S Aribisala Nicola J Armstrong Volker Arolt Eric Artiges Rosa Ayesa-Arriola Vatche G Baboyan Tobias Banaschewski Mark E Bastin Bernhard T Baune John Blangero Arun L W Bokde Premika S W Boedhoe Anushree Bose Silvia Brem Henry Brodaty Uli Bromberg Samantha Brooks Christian Büchel Jan Buitelaar Vince D Calhoun Dara M Cannon Anna Cattrell Yuqi Cheng Patricia J Conrod Annette Conzelmann Aiden Corvin Benedicto Crespo-Facorro Fabrice Crivello Udo Dannlowski Greig I de Zubicaray Sonja M C de Zwarte Ian J Deary Sylvane Desrivières Nhat Trung Doan Gary Donohoe Erlend S Dørum Stefan Ehrlich Thomas Espeseth Guillén Fernández Herta Flor Jean-Paul Fouche Vincent Frouin Masaki Fukunaga Jürgen Gallinat Hugh Garavan Michael Gill Andrea Gonzalez Suarez Penny Gowland Hans J Grabe Dominik Grotegerd Oliver Gruber Saskia Hagenaars Ryota Hashimoto Tobias U Hauser Andreas Heinz Derrek P Hibar Pieter J Hoekstra Martine Hoogman Fleur M Howells Hao Hu Hilleke E Hulshoff Pol Chaim Huyser Bernd Ittermann Neda Jahanshad Erik G Jönsson Sarah Jurk Rene S Kahn Sinead Kelly Bernd Kraemer Harald Kugel Jun Soo Kwon Herve Lemaitre Klaus-Peter Lesch Christine Lochner Michelle Luciano Andre F Marquand Nicholas G Martin Ignacio Martínez-Zalacaín Jean-Luc Martinot David Mataix-Cols Karen Mather Colm McDonald Katie L McMahon Sarah E Medland José M Menchón Derek W Morris Omar Mothersill Susana Munoz Maniega Benson Mwangi Takashi Nakamae Tomohiro Nakao Janardhanan C Narayanaswaamy Frauke Nees Jan E Nordvik A Marten H Onnink Nils Opel Roel Ophoff Marie-Laure Paillère Martinot Dimitri Papadopoulos Orfanos Paul Pauli Tomáš Paus Luise Poustka Janardhan Yc Reddy Miguel E Renteria Roberto Roiz-Santiáñez Annerine Roos Natalie A Royle Perminder Sachdev Pascual Sánchez-Juan Lianne Schmaal Gunter Schumann Elena Shumskaya Michael N Smolka Jair C Soares Carles Soriano-Mas Lachlan T Strike Roberto Toro Jessica A Turner Nathalie Tzourio-Mazoyer Anne Uhlmann Maria Valdés Hernández Odile A van den Heuvel Dennis van der Meer Neeltje E M van Haren Dick J Veltman Ganesan Venkatasubramanian Nora C Vetter Daniella Vuletic Susanne Walitza Henrik Walter Esther Walton Zhen Wang Joanna Wardlaw Wei Wen Lars T Westlye Robert Whelan Katharina Wittfeld Thomas Wolfers Margaret J Wright Jian Xu Xiufeng Xu Je-Yeon Yun JingJing Zhao Barbara Franke Paul M Thompson David C Glahn Bernard Mazoyer Simon E Fisher Clyde Francks

Brain Imaging Behav 2017 Oct;11(5):1497-1514

Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

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http://dx.doi.org/10.1007/s11682-016-9629-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540813PMC
October 2017
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11 Citations
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