J Dermatol Sci 2016 Dec 3;84(3):358-359. Epub 2016 Oct 3.
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8558, Okayama, Japan. Electronic address:
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Perm J 2016 1;20(4). Epub 2016 Sep 1.
Graduate Assistant in the Department of Internal Medicine at Centro Hospitalar de Trás-os-Montes e Alto Douro in Vila Real, Portugal.
Int J Dermatol 2007 Nov;46(11):1177-9
Department of Dermatology, Inonu University School of Medicine, Malatya, Turkey.
Background: Although the diagnosis of herpes simplex virus (HSV) and varicella zoster virus (VZV) infections is usually made clinically, the Tzanck test, electron microscopy, viral culture, polymerase chain reaction (PCR), and serologic tests can be utilized to verify the diagnosis.
Methods: We conducted a study on a total of 98 patients (77 patients with recurrent herpes simplex and 21 patients with herpes zoster) to evaluate the reliability and reproducibility of the Tzanck test in comparison with PCR.
Results: In herpes virus infections, the general positivity rates of the Tzanck test and PCR were 61. Read More
J Cutan Pathol 2012 Oct 9;39(10):929-35. Epub 2012 Aug 9.
Department of Pathology, NorthShore University Health System, Evanston, IL, USA.
Background: Herpetic dermatitis due to herpes simplex virus (HSV) and varicella zoster virus (VZV) can present with similar clinical and histopathologic features. Further confounding matters, viral cytopathic changes are not always observed in biopsy specimens. Therefore, use of polymerase chain reaction (PCR) analysis can play an integral role in the definitive diagnosis of herpetic dermatitis and in the distinction of HSV-1/HSV-2 from VZV. Read More
Diagn Mol Pathol 2003 Jun;12(2):103-7
Department of Pathology, The Ohio State University Medical Center S305E Rhodes Hall, 450 W 10th Avenue Columbus, OH 43210, USA.
The potential for a bioterrorism-induced smallpox outbreak has been much discussed of late. The literature of the late 1960s stressed that the distinction between smallpox and the other viral-induced vesicle-forming diseases, namely varicella zoster and disseminated herpes simplex, was difficult to make. Given that the cutaneous manifestations of smallpox would be among the initial symptoms, we reviewed 2 cases of smallpox diagnosed in South America in the 1970s in conjunction with 9 cases of multiple skin vesicles diagnosed as either disseminated herpes simplex or varicella-zoster. Read More