Physical exercise induces structural alterations in the hippocampal astrocytes: exploring the role of BDNF-TrkB signaling.

Authors:
Dr. Atoossa Fahimi, MD, PsyM
Dr. Atoossa Fahimi, MD, PsyM
Stanford University School of Medicine
Postdoc Fellow/ Research Associate
Psychiatry-Neuroscience
Palo Alto, CA | United States
Dr Mehmet Akif Baktir, MD
Dr Mehmet Akif Baktir, MD
Stanford University School of Medicine
Visiting Researcher
Physiology
Turkey
Prof Ahmad Salehi, M.D., Ph.D.
Prof Ahmad Salehi, M.D., Ph.D.
Stanford University School of Medicine
Professor
Palo Alto, CA | United States

Brain Struct Funct 2017 May 29;222(4):1797-1808. Epub 2016 Sep 29.

VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.

While it has been known that physical activity can improve cognitive function and protect against neurodegeneration, the underlying mechanisms for these protective effects are yet to be fully elucidated. There is a large body of evidence indicating that physical exercise improves neurogenesis and maintenance of neurons. Yet, its possible effects on glial cells remain poorly understood. Here, we tested whether physical exercise in mice alters the expression of trophic factor-related genes and the status of astrocytes in the dentate gyrus of the hippocampus. In addition to a significant increase in Bdnf mRNA and protein levels, we found that 4 weeks of treadmill and running wheel exercise in mice, led to (1) a significant increase in synaptic load in the dentate gyrus, (2) alterations in astrocytic morphology, and (3) orientation of astrocytic projections towards dentate granule cells. Importantly, these changes were possibly linked to increased TrkB receptor levels in astrocytes. Our study suggests that astrocytes actively respond and could indeed mediate the positive effects of physical exercise on the central nervous system and potentially counter degenerative processes during aging and neurodegenerative disorders.

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http://dx.doi.org/10.1007/s00429-016-1308-8DOI Listing
May 2017
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7 Citations
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