Genome Med 2016 09 8;8(1):93. Epub 2016 Sep 8.
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
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Endocrinology 2014 Jul 5;155(7):2578-88. Epub 2014 May 5.
Endocrine Program (M.A.A., C.Z., S.M., D.K.S.), Graduate Program in Neuroscience (M.A.A.), Graduate Program in Endocrinology and Animal Biosciences (C.Z.), and Department of Animal Sciences (S.M., D.K.S.), Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901.
Early-life ethanol feeding (ELAF) alters the metabolic function of proopiomelanocortin (POMC)-producing neurons and the circadian expression of clock regulatory genes in the hypothalamus. We investigated whether the circadian mechanisms control the action of ELAF on metabolic signaling genes in POMC neurons. Gene expression measurements of Pomc and a selected group of metabolic signaling genes, Stat3, Sirt1, Pgc1-α, and Asb4 in laser-captured microdissected POMC neurons in the hypothalamus of POMC-enhanced green fluorescent protein mice showed circadian oscillations under light/dark and constant darkness conditions. Read More
Endocrinology 2010 Jan 24;151(1):134-42. Epub 2009 Nov 24.
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ankyrin repeat and suppressor of cytokine signaling box-containing protein 4 (Asb-4) is specifically expressed in the energy homeostasis-related brain areas and colocalizes with proopiomelanocortin (POMC) neurons of the arcuate nucleus (ARC). Injection of insulin into the third ventricle of the rat brain increased Asb-4 mRNA expression in the paraventricular nucleus but not in the ARC of the hypothalamus, whereas injection of leptin (ip) increased Asb-4 expression in both mouse paraventricular nucleus and ARC. A transgenic mouse in which Myc-tagged Asb-4 is specifically expressed in POMC neurons of the ARC was made and used to study the effects of Asb-4 on ingestive behavior and metabolic rate. Read More
Part Fibre Toxicol 2017 06 23;14(1):20. Epub 2017 Jun 23.
Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China.
Background: Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown that exposure to ambient fine particles (PM) is associated with abnormal fetal development. However, its long-term metabolic effects on offspring have not been systematically investigated. Read More
Endocrinology 2008 Feb 15;149(2):470-5. Epub 2007 Nov 15.
Unité de Neurosciences et Physiologie Adaptatives, Equipe Associée 4052, Bâtiment SN4, 2ème étage, Université des Sciences et Technologies de Lille, 59655, Villeneuve d'Ascq Cédex, France.
A growing body of evidence suggests that maternal undernutrition sensitizes the offspring to the development of energy balance metabolic disorders such as type 2 diabetes, dyslipidemia, and obesity. The present study aimed at examining the impact of maternal undernutrition on leptin plasma levels in newborn male rats and on the arcuate nucleus proopiomelanocortin (POMC) and neuropeptide Y (NPY) neurons that are major leptin targets. Using a model of perinatal maternal 50% food-restricted diet (FR50) in the rat, we evaluated leptin plasma levels and hypothalamic POMC and NPY gene expression from postnatal day (PND) 4 to PND30 in both control and FR50 offspring. Read More