Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.

J Nat Prod 2016 09 2;79(9):2264-9. Epub 2016 Sep 2.

Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.

Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00371DOI Listing
September 2016
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