Neth J Med 2016 Jul;74(6):272
Department of Internal Medicine, Division of Tropical Diseases, Academic Medical Centre, Amsterdam, the Netherlands.
J Drugs Dermatol 2003 Dec;2(6):662-3
Section of Dermatology, Department of Medicine, University of Chicago Hospitals, Chicago, Illinois 60637-1470, USA.
An uncommon manifestation of phototoxicity, photo-onycholysis results in the separation of the distal nail from the nail bed. Photo-onycholysis may follow the use of various medications or may occasionally be idiopathic. We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris. Read More
Pediatr Rev 2015 Mar;36(3):e8-10
Pediatric Medicine Division, Sick Kids Hospital, Toronto, Ontario, Canada.
Doxycycline is a classically implicated cause of phototoxic reactions. Photo-onycholysis is a rare manifestation of phototoxicity. Nail changes may typically include nail pain, subungual hemorrhages, or distal onycholysis. Read More
BMJ 2004 Jul;329(7460):265
Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5327 MH 's-Hertogenbosch, Netherlands.
Ugeskr Laeger 1997 Jun;159(25):3965-7
Peace Corps, Madagaskar.
A case of phototoxic onycholysis secondary to treatment with doxycycline is presented. Tetracyclines are known to provoke photosensitivity reactions in some individuals exposed to sunlight. The typical photo-toxic manifestation is erythema, but cases with onycholysis have also been reported in the past. Read More