Lab Chip 2016 09 15;16(18):3454-9. Epub 2016 Aug 15.
Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin 9, Ireland.
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Front Cardiovasc Med 2016 26;3:43. Epub 2016 Oct 26.
Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.
Background: Endothelial dysfunction caused by increased oxidative stress is a critical initiator of macro- and micro-vascular disease development in diabetic patients. Ipragliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, offers a novel approach for the treatment of diabetes by enhancing urinary glucose excretion. The aim of this study was to examine whether ipragliflozin attenuates endothelial dysfunction in diabetic mice. Read More
PLoS One 2016 11;11(1):e0146947. Epub 2016 Jan 11.
Centro Regional de Estudios Genómicos, Universidad Nacional de La Plata, La Plata, Argentina.
Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. Read More
Tissue Eng Part A 2014 Aug 21;20(15-16):2213-23. Epub 2014 Mar 21.
1 Department of Surgery, St. Vincent's Hospital, University of Melbourne , Fitzroy, Victoria, Australia .
Hyaline cartilage repair is a significant challenge in orthopedics and current techniques result in formation of fibrocartilage. Human infrapatellar fat pad (hIPFP)-derived mesenchymal stem cells (MSCs) are capable of differentiation into multiple tissue lineages, including cartilage and bone. Chondrogenesis is a crucial part of normal skeletal development but the molecular mechanisms are yet to be completely defined. Read More
Eur J Med Chem 2013 Oct 13;68:385-93. Epub 2013 Aug 13.
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, China.
A cascade operation was designed to synthesize nine coumarin-substituted dihydropyrazoles with only one or two phenolic hydroxyl groups contained. Antioxidant abilities of the obtained compounds were evaluated by inhibiting 2,2'-azobis(2-amidinopropanehydrochloride) (AAPH)-, Cu2+/glutathione (GSH)-, and .OH-induced oxidation of DNA. Read More
Nephrol Dial Transplant 2013 Aug 5;28(8):2139-45. Epub 2013 Jun 5.
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Background: Endotoxemia is common in peritoneal dialysis (PD) patients, and circulating lipopolysaccharide (LPS) level is related to the degree of systemic inflammation and atherosclerosis. We hypothesize that circulating bacterial DNA, another microbial component, correlates with the degree of systemic inflammation and predicts the survival of new PD patients.
Methods: We measured the plasma bacterial DNA level in the archive blood samples of 300 consecutive new PD patients. Read More