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Iran J Allergy Asthma Immunol 2021 Jan 30;20(1):33-45. Epub 2021 Jan 30.

Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

The elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poor clinical outcomes, especially in pro-inflammatory states such as surgical injuries and severe hemorrhages. Therefore, it was hypothesized whether NLR value at the time of admission could be a prognostic indicator of hospital mortality in trauma patients. This retrospective cohort study was conducted on 865 trauma patients referred to Rajaee Hospital between April 2016 and July 2019. Read More

Drug Alcohol Depend 2021 Feb 15;221:108611. Epub 2021 Feb 15.

Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. Electronic address:

Background: Adolescent alcohol use was found to be influenced by parental and peer alcohol use. Drinking behaviors also differed by gender. However, previous studies mainly focused on adolescents' substance use in relation to the same substance use among their salient others. Read More

Diagn Microbiol Infect Dis 2021 Feb 12;100(2):115347. Epub 2021 Feb 12.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Objective: To evaluate determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection.

Materials And Methods: Hospitalized patients with SARS-CoV-2 positive nasopharyngeal RT-PCR were included in a single-center, retrospective study. Patients were divided in 2 groups according to the timing of viral clearance [≤14 days, "early clearance (EC)" and >14 days, "late clearance (LC)"]. Read More

J Surg Res 2021 Feb 24;263:63-70. Epub 2021 Feb 24.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: Molecular hydrogen (H) has been used in clinical cases. However, there are few studies of H therapy to treat sepsis, and anti-inflammatory mechanisms of H are mostly unknown. We aimed to confirm effects of H therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Read More

J Card Fail 2021 Feb 24. Epub 2021 Feb 24.

Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium; Department of Laboratory Medicine, KU Leuven, UZ Leuven, Leuven, Belgium; Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.

Background: Alterations in myocardial mitochondrial function and metabolism have been implicated in the pathophysiology of heart failure with reduced ejection fraction (HFrEF). The impact of mechanical dyssynchrony and its alleviation through cardiac resynchronization therapy (CRT) on myocardial mitochondrial function and metabolism remain poorly understood.

Methods: HFrEF patients with an indication for CRT underwent targeted metabolomic analysis of 84 energetic substrates at baseline (coronary sinus and peripheral venous blood). Read More