J Control Release 2016 09 29;238:157-165. Epub 2016 Jul 29.
Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
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Int J Mol Sci 2017 Jul 25;18(8). Epub 2017 Jul 25.
Imaging Division, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherland.
Microbubbles-assisted ultrasound (USMB) has shown promise in improving local drug delivery. The formation of transient membrane pores and endocytosis are reported to be enhanced by USMB, and they contribute to cellular drug uptake. Exocytosis also seems to be linked to endocytosis upon USMB treatment. Read More
Ultrasonics 2015 Mar 19;57:36-43. Epub 2014 Oct 19.
Department of Physics, Ryerson University, Toronto, Canada. Electronic address:
Background: Gold nanorod (AuNR) laser therapy (LT) is a non-invasive method of increasing the temperature of a target tissue using near infrared light. In this study, the effects of ultrasound and microbubbles (USMB) with AuNR and LT were investigated on cell viability.
Methods: MDA-MB-231 cells in suspension were treated with three different treatment combinations of AuNR, LT and USMB (Pneg=0. Read More
Adv Exp Med Biol 2016 ;880:263-91
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, CA, USA.
Therapeutic efficacy of both traditional chemotherapy and gene therapy in cancer is highly dependent on the ability to deliver drugs across natural barriers, such as the vessel wall or tumor cell membranes. In this regard, sonoporation induced by ultrasound-guided microbubble (USMB) destruction has been widely investigated in the enhancement of therapeutic drug delivery given it can help overcome these natural barriers, thereby increasing drug delivery into cancer. In this chapter we discuss challenges in current cancer therapy and how some of these challenges could be overcome using USMB-mediated drug delivery. Read More
BMC Biotechnol 2017 05 18;17(1):45. Epub 2017 May 18.
Department of Physics, Ryerson University, 350 Victoria Street Toronto, Ontario, M5B 2K3, Canada.
Background: Ultrasound and microbubbles (USMB) have been shown to enhance the intracellular uptake of molecules, generally thought to occur as a result of sonoporation. The underlying mechanism associated with USMB-enhanced intracellular uptake such as membrane disruption and endocytosis may also be associated with USMB-induced release of cellular materials to the extracellular milieu. This study investigates USMB effects on the molecular release from cells through membrane-disruption and exocytosis. Read More