Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Authors:
Dr Sanoop K Zachariah, MS,FRCS,FMAS,FIAGES,FACRSI,FBMS
Dr Sanoop K Zachariah, MS,FRCS,FMAS,FIAGES,FACRSI,FBMS
M.O.S.C Medical College
PROFESSOR OF SURGERY
COCHIN, KERALA | INDIA
Dr. Mushira Abdulaziz Enani, MD
Dr. Mushira Abdulaziz Enani, MD
Medical Specialties Department
Consultant
ID
Riyadh | Saudi Arabia
Dr Agron Dogjani, MD, PhD, FACS
Dr Agron Dogjani, MD, PhD, FACS
University Hospital of Trauma
Professor Associate of Surgery
General Surgeon
Tirana | Albania
Goran Augustin, MD, Phd
Goran Augustin, MD, Phd
University Hospital Center Zagreb
Abdominal Surgeon
Zagreb | Croatia
Prof. Joseph Effiong Eyo, PhD
Prof. Joseph Effiong Eyo, PhD
University of Nigeria
Nsukka, Enugu | Nigeria
Prof. Hany E Marei, PhD
Prof. Hany E Marei, PhD
Qatar University
Project Manager Biomedical Research Center, Qatar University
Doha, Doha | Qatar
Shamshul Ansari
Shamshul Ansari
Tribhuvan University Teaching Hospital
Gabriel Trueba, PhD
Gabriel Trueba, PhD
Universidad San Francisco de Quito
Director of postgraduate programs in Microbiology
Quito, Pichincha | Ecuador
Dr Katia Iskandar, PHARM.D, MHS, AMES, PhD candidate
Dr Katia Iskandar, PHARM.D, MHS, AMES, PhD candidate
Paul SABATIER , UT3, INSERM, UMR 1027, Toulouse ,France
PhD candidate-3rd year
Toulouse, Midi pyrenees | France
Gereltuya Dorj, PhD, MSc
Gereltuya Dorj, PhD, MSc
Mongolian National University of Medical Sciences
Lecturer
Pharmacy practice
Ulaanbaatar | Mongolia
Prof. Wagih Ghnnam, MD
Prof. Wagih Ghnnam, MD
Mansoura University Faculty of Medicine
professor
Laparoscopic surgery,trauma and emergency surgery
Mansoura, dakahlia | Egypt
Massimo Sartelli Dieter G Weber Etienne Ruppé Matteo Bassetti Brian J Wright Luca Ansaloni Fausto Catena Federico Coccolini Fikri M Abu-Zidan Raul Coimbra Ernest E Moore Frederick A Moore Ronald V Maier Jan J De Waele Andrew W Kirkpatrick Ewen A Griffiths Christian Eckmann Adrian J Brink John E Mazuski Addison K May Rob G Sawyer Dominik Mertz Philippe Montravers Anand Kumar Jason A Roberts Jean-Louis Vincent Richard R Watkins Warren Lowman Brad Spellberg Iain J Abbott Abdulrashid Kayode Adesunkanmi Sara Al-Dahir Majdi N Al-Hasan Ferdinando Agresta Asma A Althani Rashid Ansumana Miklosh Bala Zsolt J Balogh Oussama Baraket Aneel Bhangu Marcelo A Beltrán Michael Bernhard Walter L Biffl Marja A Boermeester Stephen M Brecher Jill R Cherry-Bukowiec Otmar R Buyne Miguel A Cainzos Kelly A Cairns Adrian Camacho-Ortiz Sujith J Chandy Asri Che Jusoh Alain Chichom-Mefire Caroline Colijn Francesco Corcione Yunfeng Cui Daniel Curcio Samir Delibegovic Zaza Demetrashvili Belinda De Simone Sameer Dhingra José J Diaz Isidoro Di Carlo Angel Dillip Salomone Di Saverio Michael P Doyle Hervé Dupont Soumitra R Eachempati Valery N Egiev Paula Ferrada Joseph R Fitchett Gustavo P Fraga Nathalie Guessennd Helen Giamarellou George Gkiokas Staphanie R Goldberg Carlos Augusto Gomes Harumi Gomi Manuel Guzmán-Blanco Mainul Haque Sonja Hansen Andreas Hecker Wolfgang R Heizmann Torsten Herzog Adrien Montcho Hodonou Suk-Kyung Hong Reinhold Kafka-Ritsch Lewis J Kaplan Garima Kapoor Aleksandar Karamarkovic Martin G Kees Jakub Kenig Ronald Kiguba Peter K Kim Yoram Kluger Vladimir Khokha Kaoru Koike Kenneth Y Y Kok Victory Kong Matthew C Knox Kenji Inaba Arda Isik Rao R Ivatury Maurizio Labbate Francesco M Labricciosa Pierre-François Laterre Rifat Latifi Jae Gil Lee Young Ran Lee Marc Leone Ari Leppaniemi Yousheng Li Stephen Y Liang Tonny Loho Marc Maegele Sydney Malama Ignacio Martin-Loeches Sanjay Marwah Amos Massele Michael McFarlane Renato Bessa Melo Ionut Negoi David P Nicolau Carl Erik Nord Richard Ofori-Asenso AbdelKarim H Omari Carlos A Ordonez Mouaqit Ouadii Gerson Alves Pereira Júnior Diego Piazza Guntars Pupelis Timothy Miles Rawson Miran Rems Sandro Rizoli Claudio Rocha Boris Sakakushev Miguel Sanchez-Garcia Norio Sato Helmut A Segovia Lohse Gabriele Sganga Boonying Siribumrungwong Vishal G Shelat Kjetil Soreide Rodolfo Soto Peep Talving Jonathan V Tilsed Jean-Francois Timsit Ngo Tat Trung Jan Ulrych Harry van Goor Andras Vereczkei Ravinder S Vohra Imtiaz Wani Waldemar Uhl Yonghong Xiao Kuo-Ching Yuan Jean-Ralph Zahar Tanya L Zakrison Antonio Corcione Rita M Melotti Claudio Viscoli Perluigi Viale

World J Emerg Surg 2016 15;11:33. Epub 2016 Jul 15.

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant' Orsola Hospital, University of Bologna, Bologna, Italy.

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

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http://dx.doi.org/10.1186/s13017-016-0089-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946132PMC
May 2018
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