Progesterone induces the expression of lipocalin-2 through Akt-c-Myc pathway during mouse decidualization.

FEBS Lett 2016 08 29;590(16):2594-602. Epub 2016 Jul 29.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The expression of Lcn2 in stromal cells is under the control of progesterone through Akt-c-Myc signaling pathway. Data from Lcn2 knockdown and recombinant protein treatments indicate that Lcn2 promotes mPGES-1 expression in stromal cells. The expression of Lcn2 and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS), indicating that Lcn2 mediates LPS-induced inflammation. These findings shed light on the role of Lcn2 during decidualization.

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http://dx.doi.org/10.1002/1873-3468.12304DOI Listing
August 2016
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References

(Supplied by CrossRef)
Reflections on rodent implantation
Cha et al.
Adv Anat Embryol Cell Biol 2015

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