Carbon-ion pencil beam scanning for thoracic treatment - initiation report and dose metrics evaluation.

Authors:
Masataka Karube
Masataka Karube
Research Center for Charged Particle Therapy
Shinichiro Mori
Shinichiro Mori
National Institute of Radiological Sciences
Japan
Hiroshi Tsuji
Hiroshi Tsuji
Kitakyushu-Tsuyazaki Hospital
Japan
Naoyoshi Yamamoto
Naoyoshi Yamamoto
Research Center Hospital for Charged Particle Therapy
Mio Nakajima
Mio Nakajima
Research Center Hospital for Charged Particle Therapy
Keiichi Nakagawa
Keiichi Nakagawa
University of Tokyo Hospital
Japan
Tadashi Kamada
Tadashi Kamada
National Institute of Radiological Sciences
Japan

J Radiat Res 2016 Sep 5;57(5):576-581. Epub 2016 Jul 5.

Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Chiba 263-8555, Japan.

Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions under free-breathing conditions as a clinical trial. This study aimed to investigate this treatment in the lungs in comparison with passive scattering CIRT. Five patients had thoracic tumors treated with carbon-ion scanned beams using respiratory gating. We analyzed the actual treatments and calculated passive scattering treatment plans based on the same planning CT. We evaluated tumor size until 3 months post treatment and each treatment plan regarding dose delivered to 95% of the clinical target volume (CTV-D95), mean lung dose, percentage of lung receiving at least 5 Gy (RBE) (Lung-V5), Lung-V10, Lung-V20, heart maximum dose (Dmax), esophagus Dmax, cord Dmax and skin Dmax. Obvious tumor deterioration was not observed up to 3 months post treatment. The dose evaluation metrics were similar item by item between respiratory-gated scanned CIRT and passive scattering CIRT. In conclusion, scanned beam CIRT provided treatments equivalent to passive scattering CIRT for thoracic tumors. Increased sample numbers and longer-term observation are needed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045082PMCFound
http://dx.doi.org/10.1093/jrr/rrw057DOI ListingPossible
September 2016
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