Post-translational regulation of inflammasomes.

Cell Mol Immunol 2017 01 27;14(1):65-79. Epub 2016 Jun 27.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-7288, USA.

Inflammasomes play essential roles in immune protection against microbial infections. However, excessive inflammation is implicated in various human diseases, including autoinflammatory syndromes, diabetes, multiple sclerosis, cardiovascular disorders and neurodegenerative diseases. Therefore, precise regulation of inflammasome activities is critical for adequate immune protection while limiting collateral tissue damage. In this review, we focus on the emerging roles of post-translational modifications (PTMs) that regulate activation of the NLRP3, NLRP1, NLRC4, AIM2 and IFI16 inflammasomes. We anticipate that these types of PTMs will be identified in other types of and less well-characterized inflammasomes. Because these highly diverse and versatile PTMs shape distinct inflammatory responses in response to infections and tissue damage, targeting the enzymes involved in these PTMs will undoubtedly offer opportunities for precise modulation of inflammasome activities under various pathophysiological conditions.

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Source
http://www.nature.com/articles/cmi201629
Publisher Site
http://dx.doi.org/10.1038/cmi.2016.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214939PMC
January 2017
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