Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

Authors:
Sooraj Baijnath
Sooraj Baijnath
University of KwaZulu-Natal
South Africa
Dr Adeola Shobo, PhD
Dr Adeola Shobo, PhD
McGill University
Dr
Montreal , McGill University | Canada
Linda A Bester
Linda A Bester
University of KwaZulu-Natal
Pietermaritzburg | South Africa
Gert Kruger
Gert Kruger
University of Johannesburg
South Africa
Per I Arvidsson
Per I Arvidsson
Uppsala University
Tricia Naicker
Tricia Naicker
School of Health Sciences

J Mol Histol 2016 Aug 21;47(4):429-35. Epub 2016 Jun 21.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.

A study was undertaken to determine the neuroprotective potential of Linezolid (LIN) in an animal model. Female Sprague-Dawley rats were either given a single (100 mg/kg) dose or treated daily for 4 weeks. A validated LC-MS/MS method was used to measure LIN levels in plasma and brain, this was paired with mass spectrometry imaging to determine the tissue spatial distribution of the drug. The results showed that after a single dose there was poor penetration of the drug into the brain. With multiple doses there were high tissue levels, with the drug reaching steady state in subsequent weeks. LIN displayed a promising distribution pattern with localisation in the brainstem. Systemic circulation is fed into the brain by the carotid and vertebral arteries which enter through the brain stem, therefore high drug concentrations is this area may protect against infectious agents entering via this route.

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http://dx.doi.org/10.1007/s10735-016-9685-0DOI Listing
August 2016
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