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Semin Reprod Med 2021 Mar 1. Epub 2021 Mar 1.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands.

This review summarizes the existing information concerning the genetic background of menopause and primary ovarian insufficiency (POI). There is overwhelming evidence that majority of genes are involved in double-strand break repair, mismatch repair, and base excision repair. The remaining loci were involved in cell energy metabolism and immune response. Read More

Curr Opin Genet Dev 2021 Feb 26;69:42-47. Epub 2021 Feb 26.

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA. Electronic address:

Naturalists leading up to the early 20th century were captivated by the diversity of limb form and function and described its development in a variety of species. The advent of discoveries in genetics followed by molecular biology led to focused efforts in few 'model' species, namely mouse and chicken, to understand conserved mechanisms of limb axis specification and development of the musculoskeletal system. 'Non-traditional' species largely fell by the wayside until their recent resurgence into the spotlight with advances in next-generation sequencing technologies (NGS). Read More

Vet Parasitol 2021 Feb 19;291:109391. Epub 2021 Feb 19.

School of Veterinary Science, Massey University, Palmerston North, New Zealand. Electronic address:

Theileria orientalis is a tick‒borne intracellular parasite of red blood cells that causes severe and mild infections in various ruminants worldwide. To date there have been 11 types identified within this species, of which 4 types are presently found in New Zealand cattle. Since 2012, New Zealand has suffered a substantial epidemic of infectious bovine anaemia in both dairy and beef cattle associated with the Ikeda type. Read More

Tissue Cell 2021 Feb 23;71:101512. Epub 2021 Feb 23.

Department of Zoology, Faculty of Science, Al Azhar University (Assiut Branch), 71524 Assiut, Egypt.

Although microplastics (MPs) have received increasing focus and currently have become an emerging area of research, there is limited knowledge about their effect on whole body histology of fish. In this study, tilapia (Oreochromis niloticus) early juveniles were exposed to 1, 10, or 100 mg/L of MPs for 15 days and 15 days post-exposure, after which whole body histological examinations were performed. Histological analysis of kidney revealed congestion of blood capillaries, inflammatory cells, loss of basophilic cytoplasm in several tubules, vacuolated tubules, shrinking of convoluted tubules, widening of intertubular space, complete deformation, glomerular atrophy, vacuolated glomerular cells, and signs of fatty tubules. Read More

J Hazard Mater 2021 Feb 24;414:125514. Epub 2021 Feb 24.

Nanoscience and Nanoengineering, South Dakota School of Mines and Technology, 501 East Saint Joseph Street, Rapid City, SD, USA 57701; BioSystems Networks & Translational Research (BioSNTR), 501 East Saint Joseph Street, Rapid City, SD, USA 57701. Electronic address:

Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles have emerged as a promising platform for drug delivery and controlled release. Considering most ZIF-8 nanoparticle drug carriers are designed to be administered intravenously, and thus would directly contact vascular smooth muscle cells (VSMCs) in many circumstances, the potential interactions of ZIF-8 nanoparticles with VSMCs require investigation. Here, the effects of low doses of ZIF-8 nanoparticles on VSMC morphology, actin organization, and contractility are investigated. Read More