Biofunctionalized nanoparticles: an emerging drug delivery platform for various disease treatments.

Drug Discov Today 2016 08 11;21(8):1303-12. Epub 2016 Jun 11.

School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea. Electronic address:

Biological barriers, such as phagocytosis and nonspecific distribution, are major factors limiting the clinical translation of nanomedicine. Biomimetic and bioengineering strategies have been used to overcome these challenges. In particular, natural cell membrane-based biofunctionalized nanoparticles (CMFNPs) have gained widespread attention owing to their cell surface mimetic characteristics and tailored nanomaterial features. These hybrid nanocarriers show strong potential for the delivery of myriad therapeutic agents. Herein, we highlight the most recent advances in CMFNP-based drug delivery systems and address the challenges and opportunities in the field.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2016.06.005DOI Listing
August 2016
7 Reads

Publication Analysis

Top Keywords

drug delivery
8
biofunctionalized nanoparticles
8
attention cell
4
widespread attention
4
cell surface
4
mimetic characteristics
4
tailored nanomaterial
4
characteristics tailored
4
gained widespread
4
surface mimetic
4
nanoparticles cmfnps
4
overcome challenges
4
strategies overcome
4
bioengineering strategies
4
challenges natural
4
natural cell
4
nanomaterial features
4
cell membrane-based
4
cmfnps gained
4
hybrid nanocarriers
4

Similar Publications