Technical Aspects and Benefits of Experimental Mouse Lung Transplantation.

Arch Bronconeumol 2016 Dec 31;52(12):596-604. Epub 2016 May 31.

Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, España; Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, España; CIBER de Enfermedades Respiratorias (CIBERES), España. Electronic address:

In recent years, the number of lung transplantations performed as the last option for many respiratory diseases has grown considerably, both in adults and children. However, the causes for the relatively short survival of lungs compared to other organ transplants still need to be studied. Techniques have improved since the 1950s when experimental lung transplantation began, and the different animal species used now include rodents. The advantage of using these small species is that the surgical model has been expanded and standardized, and different respiratory problems can be studied. In this review we examine the different technical strategies used in experimental transplantation in rats and mice, focusing on surgical techniques and anesthesia and monitoring methods, and highlighting the major contributions of mouse lung transplantation to the field.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arbres.2016.04.008DOI Listing
December 2016
4 Reads

Publication Analysis

Top Keywords

lung transplantation
12
mouse lung
8
experimental lung
4
1950s experimental
4
improved 1950s
4
transplantation began
4
rats mice
4
species include
4
animal species
4
began animal
4
survival lungs
4
techniques improved
4
organ transplants
4
focusing surgical
4
compared organ
4
transplants studied
4
studied techniques
4
transplantation rats
4
mice focusing
4
surgical techniques
4

Similar Publications