Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.

Authors:
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Yevhen Fatieiev
Yevhen Fatieiev
Smart Hybrid Materials Laboratory (SHMs)
Khachatur Julfakyan
Khachatur Julfakyan
Smart Hybrid Materials Laboratory
Japan
Jie Lu
Jie Lu
Shanghai Tenth People's Hospital
China
Abdul-Hamid Emwas
Abdul-Hamid Emwas
Saudi Arabia
Dalaver H Anjum
Dalaver H Anjum
King Abdullah University of Science and Technology (KAUST)
Saudi Arabia
Haneen Omar
Haneen Omar
Smart Hybrid Materials Laboratory
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Jonsson Comprehensive Cancer Center
United States

Chemistry 2016 Oct 30;22(42):14806-14811. Epub 2016 Jun 30.

Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

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October 2016
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