Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells.

Authors:
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Yevhen Fatieiev
Yevhen Fatieiev
Smart Hybrid Materials Laboratory (SHMs)
Haneen Omar
Haneen Omar
Smart Hybrid Materials Laboratory
Dalaver H Anjum
Dalaver H Anjum
King Abdullah University of Science and Technology (KAUST)
Saudi Arabia
Andrey Gurinov
Andrey Gurinov
Freie Universität Berlin
Jie Lu
Jie Lu
Shanghai Tenth People's Hospital
China
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Jonsson Comprehensive Cancer Center
United States
Jeffrey I Zink
Jeffrey I Zink
University of California
United States

Chemistry 2016 07 1;22(28):9607-15. Epub 2016 Jun 1.

Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

Despite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta-phenylene bridges, and we conducted a comparative structure-property relationship investigation with para-phenylene-bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para-based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene-ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co-delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing.

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July 2016
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