eNeuro 2016 Mar-Apr;3(2). Epub 2016 May 13.
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, Maryland 20892.
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J Neurosci 2013 Mar;33(13):5454-65
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095-1763, USA.
Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20-50% of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in mammals, e.g. Read More
J Neurophysiol 1997 Apr;77(4):1853-60
Department of Neurobiology, University of California, Los Angeles 90095-1527, USA.
A key distinction between neural pacemaker and conventional network models for the generation of breathing rhythm in mammals is whether phasic reciprocal inhibitory interactions between inspiratory and expiratory neurons are required. In medullary slices from neonatal rats generating respiratory-related rhythm, we measured the phasic inhibitory inputs to expiratory neurons with the use of whole cell patch clamp in the hypothesized rhythm generation site, the pre-Bötzinger complex (pre-BötC). Expiratory neurons, which generate tonic impulse activity during the expiratory period, exhibited inhibitory postsynaptic potentials (IPSPs) synchronized to the periodic inspiratory bursts of the hypoglossal nerve root (XIIn). Read More
Brain Res 2010 Jul 17;1344:134-47. Epub 2010 May 17.
Dipartimento di Scienze Fisiologiche, Università degli Studi di Firenze, Viale GB Morgagni 63, I-50134 Firenze, Italy.
The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and glycine receptor agonists and antagonists. GABA(A) receptor blockade by bicuculline (5mM) or gabazine (2mM) within the BötC induced strong depression of respiratory activity up to apnea. The latter was reversed by hypercapnia. Read More
J Neurophysiol 2009 Apr 18;101(4):2134-45. Epub 2009 Feb 18.
Dept. of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
One of the characteristics of respiratory motor output is the presence of fast synchronous oscillations, at rates far exceeding the basic breathing rhythm, within a given functional population. However, the mechanisms responsible for organizing phrenic output into two dominant bands in vivo, medium (MFO)- and high (HFO)-frequency oscillations, have yet to be elucidated. We hypothesize that GABA(A)ergic and glycinergic inhibition within the phrenic motor nucleus underlies the specific organization of these oscillations. Read More