All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.

Cancer Prev Res (Phila) 2016 07 17;9(7):509-11. Epub 2016 May 17.

Van Andel Research Institute, Center for Epigenetics, Grand Rapids, Michigan.

DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer and colleagues challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. Cancer Prev Res; 9(7); 509-11. ©2016 AACRSee related article by Sheaffer, et al., p. 534.

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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784773PMC
July 2016
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