Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine.

Authors:
Yuri Bozzi
Yuri Bozzi
University of Trento
Trento | Italy
Matteo Caleo
Matteo Caleo
CNR Neuroscience Institute
Italy

DNA Cell Biol 2016 Jun 11;35(6):257-60. Epub 2016 May 11.

2 Neuroscience Institute , National Research Council (CNR), Pisa, Italy .

Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Several lines of evidence demonstrate that inflammatory processes within the brain parenchyma contribute to recurrence and precipitation of seizures. In both epileptic patients and animal models, seizures upregulate inflammatory mediators, which in turn may enhance brain excitability. We recently showed that the C-C motif ligand 2 (CCL2) chemokine (also known as monocyte chemoattractant protein-1 [MCP-1]) mediates the seizure-promoting effects of inflammation. Systemic inflammatory challenge in chronically epileptic mice markedly enhanced seizure frequency and upregulated CCL2 expression in the brain. Selective pharmacological blockade of CCL2 synthesis or C-C chemokine receptor type 2 (CCR2) significantly suppressed inflammation-induced seizures. These results have important implications for the development of novel anticonvulsant therapies: drugs interfering with CCL2 signaling are used clinically for several human disorders and might be redirected for use in pharmacoresistant epilepsy. Here we review the role of CCL2/CCR2 signaling in linking systemic inflammation with seizure susceptibility and discuss some open questions that arise from our recent studies.

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/dna.2016.3345
Publisher Site
http://dx.doi.org/10.1089/dna.2016.3345DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
June 2016
320 Reads

Publication Analysis

Top Keywords

motif ligand
8
c-c motif
8
monocyte chemoattractant
4
type ccr2
4
redirected pharmacoresistant
4
pharmacoresistant epilepsy
4
chemokine monocyte
4
chemoattractant protein-1
4
disorders redirected
4
mediates seizure-promoting
4
receptor type
4
human disorders
4
[mcp-1] mediates
4
protein-1 [mcp-1]
4
novel anticonvulsant
4
ccl2 chemokine
4
ccl2
4
review role
4
mediators turn
4
inflammatory mediators
4

Similar Publications