Cell Cycle 2016 07 10;15(14):1811. Epub 2016 May 10.
b Department of Genetics , Cell Biology and Development, University of Minnesota , Minneapolis , MN , USA.
J Biomech 2021 Apr 5;121:110400. Epub 2021 Apr 5.
Fischell Department of Bioengineering, University of Maryland, College Park 20742, MD, USA; Maryland Biophysics Program, University of Maryland, College Park, MD 20742, USA. Electronic address:
During cancer metastasis, tumor cells undergo significant deformation in order to traverse through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow gaps, smaller than the nuclear diameter, the spatial configuration of chromatin must change along with the distribution of nuclear enzymes. Nuclear stiffness is an important determinant of the ability of cells to undergo transendothelial migration, yet no studies have been conducted to assess whether tumor cell cytoskeletal or nuclear stiffness changes during this critical process in order to facilitate passage. Read More
Curr Opin Chem Biol 2021 Apr 18;61:214-226. Epub 2021 Apr 18.
Department of Chemistry, University of Bari, via Orabona, 4, 70125, Bari, Italy. Electronic address:
Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a physiological setting. Read More
Fungal Genet Biol 2021 Apr 18:103562. Epub 2021 Apr 18.
The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR47UH, United Kingdom. Electronic address:
Magnaporthe oryzae is the causal agent of rice blast disease, the most widespread and serious disease of cultivated rice. Live cell imaging and quantitative 4D image analysis have provided new insight into the mechanisms by which the fungus infects host cells and spreads rapidly in plant tissue. In this video review article, we apply live cell imaging approaches to understanding the cell and developmental biology of rice blast disease. Read More
J Undergrad Neurosci Educ 2020 31;19(1):A124-A133. Epub 2020 Dec 31.
School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom.
Central pattern generators (CPGs) are neural networks that produce rhythmic motor activity in the absence of sensory input. CPGs produce 'fictive' behaviours which parallel activity seen in intact animals. CPG networks have been identified in a wide variety of model organisms and have been shown to be critical for generating rhythmic behaviours such as swimming, walking, chewing and breathing. Read More
Proc Natl Acad Sci U S A 2021 Apr;118(17)
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.
β-arrestins regulate many cellular functions including intracellular signaling and desensitization of G protein-coupled receptors (GPCRs). Previous studies show that β-arrestin signaling and receptor endocytosis are modulated by the plasma membrane phosphoinositide lipid phosphatidylinositol-(4, 5)-bisphosphate (PI(4,5)P). We found that β-arrestin also helped promote synthesis of PI(4,5)P and up-regulated GPCR endocytosis. Read More