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    Lung stereotactic radiotherapy for oligometastases: comparison of oligo-recurrence and sync-oligometastases.
    Jpn J Clin Oncol 2016 Jul 9;46(7):687-91. Epub 2016 May 9.
    Department of Radiology, University of Tokyo Hospital, Tokyo.
    Background: Oligometastases can be divided into sync-oligometastases and oligo-recurrence. The difference is whether the primary site is uncontrolled or controlled. The goal of this multicenter study was to evaluate treatment outcomes and factors affecting survival after stereotactic body radiotherapy for pulmonary oligometastases.

    Methods: The information after stereotactic body radiotherapy from January 2004 to April 2014 was retrospectively collected. Ninety-six patients (65 males, 31 females) were enrolled. Ten cases (10%) were sync-oligometastases, 79 cases (82%) were oligo-recurrences and 7 (7%) were unclassified oligometastases with <6 months of disease-free interval. The median disease-free interval between initial therapy and stereotactic body radiotherapy was 24 months. The median calculated biological effective dose was 105.6 Gy.

    Results: The median follow-up period was 32 months for survivors. The 3-year overall survival and relapse-free survival rates were 53% and 32%, respectively. No Grade 5 toxicity occurred. The median overall survival was 23.9 months for sync-oligometastases and 66.6 months for oligo-recurrence (P = 0.0029). On multivariate analysis, sync-oligometastases and multiple oligometastatic tumors were significant unfavorable factors for both overall survival and relapse-free survival.

    Conclusions: In stereotactic body radiotherapy for oligometastatic lung tumors, the state of oligo-recurrence has the potential of a significant prognostic factor for survival.

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    Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Kita 15-jo, Nishi 7-chome, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
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    Stereotactic Body Radiotherapy Results for Pulmonary Oligometastases: A Two-Institution Collaborative Investigation.
    Anticancer Res 2015 Sep;35(9):4903-8
    Department of Radiology, the University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
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    Patients And Methods: SBRT (stereotactic body radiotherapy) as performed for pulmonary oligometastases from January 2004 to April 2014, and patients with a biologically effective dose (BED10) ≥ 75 Gy were registered in the study. Control of the primary tumor was not a criterion: we included both oligo-recurrence and sync-oligometastases. Read More
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    Department of Radiation Oncology, University Hospital Wuerzburg, Germany; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Switzerland. Electronic address:
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    Materials And Methods: All German radiotherapy departments were contacted and invited to participate in this analysis. Read More
    Stereotactic body radiotherapy for lung metastases as oligo-recurrence: a single institutional study.
    J Radiat Res 2016 Jan 22;57(1):55-61. Epub 2015 Oct 22.
    Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan
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