Intranasal Oxytocin Selectively Modulates Social Perception, Craving, and Approach Behavior in Subjects With Alcohol Use Disorder.

J Addict Med 2016 May-Jun;10(3):182-9

Department of Neurology (JMM, DW), University of California San Francisco, San Francisco, CA; and Department of Psychiatry (JMM, PAA, JDW), University of California San Francisco, San Francisco, CA.

Objectives: A pharmacotherapy that both improves social abilities and promotes abstinence may be particularly helpful for the treatment of alcohol use disorder. Recent clinical and preclinical evidence suggests that oxytocin has prosocial and antiaddiction effects. We performed a pilot, laboratory-based, preclinical trial of oxytocin in subjects with alcohol abuse (as per Diagnostic and Statistical Manual of Mental Disorders, 4 Edition criteria) to evaluate therapeutic potential and assess tolerability.

Methods: Social perceptual ability, cue-induced craving, and approach bias for alcohol and appetitive imagery were quantified after intranasal oxytocin and placebo administration to 32 nontreatment-seeking individuals with alcohol abuse in a double-blind, crossover study. Because attachment style can moderate the effects of oxytocin, we also explored whether attachment style moderated oxytocin's effects on our behavioral measures.

Results: Oxytocin significantly improved recognition of easier items on a social perception task, but had no significant group-level effect on cue-induced craving. However, oxytocin effects on craving were moderated by attachment anxiety, with oxytocin reducing craving in more anxiously attached individuals and increasing craving in less anxiously attached individuals. Subjects did not display an approach bias to alcohol images on the placebo day, preventing meaningful analysis of this measure. Subjects did display an approach bias to appetitive images on the placebo day, which was significantly reduced by oxytocin administration. No adverse reactions were observed.

Conclusions: Intranasal oxytocin has potential to improve social perception, reduce cue-induced alcohol cravings, and reduce appetitive approach bias in subjects with alcohol abuse, and can be safely tolerated in this population. The effects of oxytocin are complex, however, and require further investigation.

Download full-text PDF

Source
http://dx.doi.org/10.1097/ADM.0000000000000213DOI Listing
February 2017
24 Reads

Publication Analysis

Top Keywords

approach bias
16
social perception
12
alcohol abuse
12
intranasal oxytocin
12
subjects alcohol
12
oxytocin
10
images placebo
8
alcohol disorder
8
attachment style
8
placebo day
8
subjects display
8
craving anxiously
8
anxiously attached
8
attached individuals
8
alcohol
8
display approach
8
effects oxytocin
8
craving approach
8
bias alcohol
8
cue-induced craving
8

Similar Publications