Oncogenic viruses: Lessons learned using next-generation sequencing technologies.

Eur J Cancer 2016 07 5;61:61-8. Epub 2016 May 5.

University Hospital Pitié Salpêtrière, Department of Medical Oncology, University Pierre and Marie Curie, Paris, France.

Fifteen percent of cancers are driven by oncogenic human viruses. Four of those viruses, hepatitis B virus, human papillomavirus, Merkel cell polyomavirus, and human T-cell lymphotropic virus, integrate the host genome. Viral oncogenesis is the result of epigenetic and genetic alterations that happen during viral integration. So far, little data have been available regarding integration mechanisms and modifications in the host genome. However, the emergence of high-throughput sequencing and bioinformatic tools enables researchers to establish the landscape of genomic alterations and predict the events that follow viral integration. Cooperative working groups are currently investigating these factors in large data sets. Herein, we provide novel insights into the initiating events of cancer onset during infection with integrative viruses. Although much remains to be discovered, many improvements are expected from the clinical point of view, from better prognosis classifications to better therapeutic strategies.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2016.03.086DOI Listing
July 2016
28 Reads

Publication Analysis

Top Keywords

host genome
8
viral integration
8
modifications host
4
viruses remains
4
mechanisms modifications
4
integration mechanisms
4
genome emergence
4
high-throughput sequencing
4
bioinformatic tools
4
infection integrative
4
integrative viruses
4
sequencing bioinformatic
4
remains discovered
4
emergence high-throughput
4
integration data
4
result epigenetic
4
oncogenesis result
4
improvements expected
4
viral oncogenesis
4
sets provide
4

Similar Publications