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Pediatr Dermatol 1987 Aug;4(2):112-22
Department of Pathology, Micheal Reese Hospital and Medical Center, Chicago, IL 60616.
Sclerema neonatorum and subcutaneous fat necrosis are rare disorders affecting the panniculus of the newborn. This review attempts to put into perspective their similarities and differences in light of historical, biochemical, pathologic, and etiologic considerations. Recent therapeutic modalities and the prognosis are discussed. Read More
Med Cutan Ibero Lat Am 1983 ;11(1):11-6
Two cases of subcutaneous fat necrosis of the newborn are reported, an infrequent disease characterized by nodules or cutaneous endurated plaques that appears a few days after birth, which histopathologic studies shows fat necrosis with formation of giant cells granulomas strange body type and the presence of needle shaped clefts corresponding to fat crystals. This is a benign disease that has to be to differentiated from sclerema neonatorum, a serious entity which coexists with another disease so we also think it could be more a symptom than an authentic thickness. The two entities are vinculated physiopathologically by the injury of the fat tissue with a minor quantity of oleic acid and a major relative proportion of palmitic and stearic acid; than that of the adult, which conditions its easy solidification. Read More
Arch Pediatr Adolesc Med 1994 Jan;148(1):61-2
Department of Dermatology, Stanford University School of Medicine, Calif.
Clin Rheumatol 1988 Dec;7(4):522-6
Service de Médecine Interne Générale, Universitaires St-Luc, Bruxelles, Belgium.
A fifty-seven-year-old woman had been suffering from chronic nodules on both legs for 17 years. The histologic findings have suggested pancreatic-disease-associated fat necrosis. Up to now, however, no pancreatic disorder has been found and several biological clues indicate that a more plausible explanation may be an immune-mediated injury of the panniculus. Read More