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    Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13.

    • Authors:
    • Mary A Brehm
      University of Texas Southwestern Medical Center
      Katie Gordon
      University of Texas Southwestern Medical Center
      Miahil Firan
      University of Texas Southwestern Medical Center
      Peter Rady
      University of Texas Medical Branch
      United States
      Nnenna Agim
      University of Texas Southwestern Medical Center
    Pediatr Dermatol 2016 May 13;33(3):e224-5. Epub 2016 Apr 13.
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
    Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (HPV), particularly subtypes 13 and 32. The disease typically presents in young Native American patients and is characterized by multiple asymptomatic papules and nodules on the oral mucosa, lips, tongue, and gingiva. The factors that determine susceptibility to FEH are unknown, but the ethnic and geographic distribution of FEH suggests that genetic predisposition, particularly having the human lymphocytic antigen DR4 type, may be involved in pathogenesis. We report a case of FEH with polymerase chain reaction detection of HPV13 in a healthy 11-year-old Hispanic girl and discuss the current understanding of disease pathogenesis, susceptibility, and treatment.
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