Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13.

Authors:
Mary A Brehm
Mary A Brehm
University of Texas Southwestern Medical Center
Katie Gordon
Katie Gordon
University of Texas Southwestern Medical Center
Miahil Firan
Miahil Firan
University of Texas Southwestern Medical Center
Peter Rady
Peter Rady
University of Texas Medical Branch
United States
Nnenna Agim
Nnenna Agim
University of Texas Southwestern Medical Center

Pediatr Dermatol 2016 May 13;33(3):e224-5. Epub 2016 Apr 13.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

Focal epithelial hyperplasia (FEH), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (HPV), particularly subtypes 13 and 32. The disease typically presents in young Native American patients and is characterized by multiple asymptomatic papules and nodules on the oral mucosa, lips, tongue, and gingiva. The factors that determine susceptibility to FEH are unknown, but the ethnic and geographic distribution of FEH suggests that genetic predisposition, particularly having the human lymphocytic antigen DR4 type, may be involved in pathogenesis. We report a case of FEH with polymerase chain reaction detection of HPV13 in a healthy 11-year-old Hispanic girl and discuss the current understanding of disease pathogenesis, susceptibility, and treatment.

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http://dx.doi.org/10.1111/pde.12862DOI Listing
May 2016
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