Life Sci 2016 May 12;153:153-62. Epub 2016 Apr 12.
Department of Pediatrics, Peking University People's Hospital, No. 11, Xi Zhi Men Street, Beijing 100044, PR China. Electronic address:
Aims: Febrile seizure (FS) is one of the most common types of seizures in childhood. Recurrent FS can result in hippocampus injury and thus impair learning capacity and memory, while the underlying molecular mechanisms are still elusive. Studies indicated that endoplasmic reticulum stress (ERS), involved in many diseases including some neurodegenerative diseases, can increase the expression of tribbles-related protein 3 (TRIB3), which thus inhibits the activity of AKT. Read More