Models for preclinical studies in aging-related disorders: One is not for all.

Authors:
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Consuelo Borras
Consuelo Borras
University of Valencia
Jean Bousquet
Jean Bousquet
Université Laval
Canada
Antonio Cano
Antonio Cano
University of Valencia
Spain
Maddalena Illario
Maddalena Illario
University of Naples Federico II
Napoli | Italy
Claudio Franceschi
Claudio Franceschi
University of Bologna
Bologna | Italy
Giuseppe Liotta
Giuseppe Liotta
University of Tor Vergata
Italy

Transl Med UniSa 2015 Dec 31;13:4-12. Epub 2016 Jan 31.

Department of Medicine and Surgery, University of Salerno, Italy.

Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment-effect relationships to human subjects. Researchers aim to demonstrate a causal relationship between an investigational agent and a disease-related phenotype in such models. Numerous factors can muddle reliable inferences about such cause-effect relationships, including biased outcome assessment due to experimenter expectations. For instance, responses in a particular inbred mouse might be specific to the strain, limiting generalizability. Selecting well-justified and widely acknowledged model systems represents the best start in designing preclinical studies, especially to overcome any potential bias related to the model itself. This is particularly true in the research that focuses on aging, which carries unique challenges, mainly attributable to the fact that our already long lifespan makes designing experiments that use people as subjects extremely difficult and largely impractical.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811343PMC
December 2015
20 Reads
4 Citations

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