Navigating pleiotropy in precision medicine: pharmacogenes from trauma to behavioral health.

Pharmacogenomics 2016 Apr 29;17(5):499-505. Epub 2016 Mar 29.

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, 1400 West 22nd Street, Sioux Falls, SD 57105, USA.

A strong emerging principle in the field of precision medicine is that variation in any one pharmacogene may impact clinical outcome for more than one drug. Variants tested in the acute care setting often have downstream implications for other drugs impacting chronic disease management. A flexible framework is needed as clinicians and scientists move toward deploying automated decision support for gene-based drug dosing in electronic medical records.

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.16.6DOI Listing
April 2016
2 Reads

Publication Analysis

Top Keywords

precision medicine
8
drugs impacting
4
implications drugs
4
impacting chronic
4
chronic disease
4
management flexible
4
disease management
4
downstream implications
4
setting downstream
4
drug variants
4
outcome drug
4
variants tested
4
tested acute
4
acute care
4
flexible framework
4
needed clinicians
4
gene-based drug
4
support gene-based
4
drug dosing
4
dosing electronic
4

Similar Publications