Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016.

Authors:
Dr Jonathan Gubbay, MBBS, BSc, MMedSc
Dr Jonathan Gubbay, MBBS, BSc, MMedSc
Public Health Ontario
Medical Microbiologist; Paediatric Infectious Diseases Physician
Medical Microbiology, Paediatric Infectious Diseases
Toronto, Ontario | Canada

Euro Surveill 2016 ;21(11):30168

British Columbia Centre for Disease Control, Vancouver, Canada.

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2015/16 vaccine effectiveness (VE) against influenza A(H1N1)pdm09 viruses. Adjusted VE showed significant protection of 64% (95% confidence interval (CI): 44-77%) overall and 56% (95%CI: 26-73%) for adults between 20 and 64 years-old against medically attended, laboratory-confirmed A(H1N1)pdm09 illness. Among the 67 A(H1N1)pdm09-positive specimens that were successfully sequenced, 62 (> 90%) belonged to the emerging genetic 6B.1 subclade, defined by S162N (potential gain of glycosylation) and I216T mutations in the haemagglutinin protein. Findings from the Canadian SPSN indicate that the 2015/16 northern hemisphere vaccine provided significant protection against A(H1N1)pdm09 illness despite genetic evolution in circulating viruses.

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Source
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.11.30168DOI Listing
September 2016
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13 Citations

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References

(Supplied by CrossRef)
Influenza activity - United States, 2014-15 season and composition of the 2015-16 influenza vaccine.
Appiah et al.
MMWR Morb Mortal Wkly Rep 2015

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