Ferrocene-Modified Phospholipid: An Innovative Precursor for Redox-Triggered Drug Delivery Vesicles Selective to Cancer Cells.

Authors:
Dr. Tomer Noyhouzer, PhD
Dr. Tomer Noyhouzer, PhD
McGill University
Electrochemistry, flow systems, sensors, ISEs, drug delivery
Montreal, Quebec | Canada

Langmuir 2016 05 21;32(17):4169-78. Epub 2016 Apr 21.

Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A OB8.

Controlled payload release is one of the key elements in the creation of a reliable drug delivery system. We report the discovery of a drug delivery vessel able to transport chemotherapeutic agents to target cancer cells and selectively trigger their release using the electrochemical activity of a ferrocene-modified phospholipid. Supported by in vitro assays, the competitive advantages of this discovery are (i) the simple one step scalability of the synthetic process, (ii) the stable encapsulation of toxic drugs (doxorubicin) during transport, and (iii) the selective redox triggering of the liposomes to harness their cytotoxic payload at the cancer site. Specifically, the redox-modified giant unilamellar vesicle and liposomes were characterized using advanced methods such as scanning electrochemical microscopy (SECM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and fluorescent imaging.

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Source
http://dx.doi.org/10.1021/acs.langmuir.6b00511DOI Listing
May 2016
119 Reads
2 Citations
4.460 Impact Factor

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