Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.

Breast Cancer Res Treat 2016 Apr 14;156(2):261-9. Epub 2016 Mar 14.

Department of Gastroenterological Surgery and Surgical Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Aldehyde dehydrogenase 1 (ALDH1) has been identified as a breast cancer stem cell marker, but its value as a predictor of prognosis and chemoresistance is controversial. This study investigated the effect of ALDH1 on prognosis and chemoresponse by breast cancer subtype. We immunohistochemically analyzed 653 invasive breast cancer specimens and evaluated correlations among clinicopathological factors, survival status, response to neoadjuvant chemotherapy, and ALDH1 expression. Of 653 specimens, 139 (21.3 %) expressed ALDH1 in tumor cells. ALDH1 expression was correlated significantly with larger tumor size, node metastasis, higher nuclear grade, and with HER2(+) and progesterone/estrogen receptor (HR)(-) subtypes. ALDH1 expression was significantly observed in HER2 type and triple-negative breast cancer (TNBC). Patients with ALDH1(+) cancers had significantly shorter disease-free survival (P < 0001) and overall survival (P = 0.044). ALDH1 expression significantly affected prognosis of luminal types, but not TNBC and HER2-enriched types. For the 234 patients treated with neoadjuvant chemotherapy, pathological complete response (pCR) rate was significantly lower in ALDH1(+) cases (13.5 vs. 30.3 %, P = 0.003). pCR and ALDH1 expression were significantly correlated in TNBC patients (P = 0.003). ALDH1(+) breast cancers tended to be aggressive, with poor prognoses. Although ALDH1(+) TNBC showed higher chemoresistance, ALDH1 had significant impact on prognosis in the luminal type but not in TNBC.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-016-3738-7DOI Listing
April 2016
38 Reads

Publication Analysis

Top Keywords

breast cancer
20
aldh1 expression
12
aldh1 prognosis
8
cancer subtype
8
prognosis chemoresistance
8
aldh1
7
cancer
5
breast
5
cells aldh1
4
aldh1 tumor
4
expressed aldh1
4
tumor cells
4
larger tumor
4
size node
4
tumor size
4
213 % expressed
4
correlated larger
4
expression correlated
4
expression 653
4
response neoadjuvant
4

References

(Supplied by CrossRef)

C Ginester et al.
Cell Stem Cell 2007

SJ Morrison et al.
Development 1997

T Reya et al.
Nature 2001

AV Molofsky et al.
Curr Opin Cell Biol 2004

RJ Ward et al.
Annu Rev Pathol 2007

K Polyak et al.
Nat Med 2006

PB Gupta et al.
Nat Med 2009

D Zhao et al.
Stem Cells 2012

M Al-Hajj et al.
Proc Natl Acad Sci USA 2003

JS Mieog et al.
BMC Cancer 2012

E Resetkova et al.
Breast Cancer Res Treat 2010

Similar Publications