Elife 2016 Mar 14;5:e13403. Epub 2016 Mar 14.
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, United States.
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J Neurophysiol 2001 Jul;86(1):59-74
Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4455, USA.
We used the testable predictions of mathematical models proposed by Butera et al. to evaluate cellular, synaptic, and population-level components of the hypothesis that respiratory rhythm in mammals is generated in vitro in the pre-Bötzinger complex (pre-BötC) by a heterogeneous population of pacemaker neurons coupled by fast excitatory synapses. We prepared thin brain stem slices from neonatal rats that capture the pre-BötC and maintain inspiratory-related motor activity in vitro. Read More
J Comput Neurosci 2011 Jun 7;30(3):607-32. Epub 2010 Oct 7.
Department of Mathematics, University of Pittsburgh, 301 Thackeray Hall, Pittsburgh, PA 15260, USA.
In mammalian respiration, late-expiratory (late-E, or pre-inspiratory) oscillations emerge in abdominal motor output with increasing metabolic demands (e.g., during hypercapnia, hypoxia, etc. Read More
Arch Ital Biol 2005 Sep;143(3-4):207-14
Dipartimento di Scienze Fisiologiche, Università di Firenze, Viale G.B. Morgagni 63, I-50134 Firenze, Italy.
The role of the Bötzinger complex (BötC) and the pre-Bötzinger complex (pre-BötC) in the genesis of the breathing pattern was investigated in anesthetized, vagotomized, paralysed and artificially ventilated rabbits making use of bilateral microinjections of kainic acid (KA) and excitatory amino acid (EAA) receptor antagonists. KA microinjections into either the BötC or the pre-BötC transiently eliminated respiratory rhythmicity in the presence of tonic phrenic activity (tonic apnea). Rhythmic activity resumed as low-amplitude, high-frequency irregular oscillations, superimposed on tonic inspiratory activity and displayed a progressive, although incomplete recovery. Read More
Eur J Neurosci 2013 Jan 4;37(2):212-30. Epub 2012 Nov 4.
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
The neural mechanisms generating rhythmic bursting activity in the mammalian brainstem, particularly in the pre-Bötzinger complex (pre-BötC), which is involved in respiratory rhythm generation, and in the spinal cord (e.g. locomotor rhythmic activity) that persist after blockade of synaptic inhibition remain poorly understood. Read More