Search Our Scientific Publications & Authors

Biochem Biophys Res Commun 2021 Feb 26;548:211-216. Epub 2021 Feb 26.

Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta Western Road, Xi'an, Shaanxi, 710061, PR China. Electronic address:

In the past decades, remarkable efforts have been made to unravel the regulation of adipose tissue metabolism, given the increasing prevalence of obesity and its huge impact on human health. Wnt signaling pathway is closely involved in this entity. As extracellular inhibitors to Wnt signaling, secreted protein Dickkopfs (Dkks) may be potential targets to combat obesity and related metabolic disorders. Read More

Transl Oncol 2021 Feb 26;14(5):101047. Epub 2021 Feb 26.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic address:

Exosomes are bioactive lipid bilayer vesicles released by most cells to mediate intercellular signal communication. Tumor cells release exosomes transmitting signals cell-to-cell and between cells and organs, which will promote tumor angiogenesis, regulate tumor stromal response, immune response, and enhance tumor cells resistance, while exosomes-derived from immune cells in tumor microenvironment play a key role in inhibiting tumor growth and killing tumor cells. Programmed cell death protein 1 (PD-1) combined with Programmed cell death protein ligand 1(PD-L1) can inhibit the activation of T cells, for tumor cells achieve immune escape by overexpressing PD-L1 and binding PD-1 on T cells. Read More

Am J Sports Med 2021 Mar 1:363546521993788. Epub 2021 Mar 1.

Department of Orthopaedic Surgery, University of California San Diego, La Jolla, California, USA.

Background: There is a need to identify and quantify mesenchymal stromal cells (MSCs) in human bone marrow aspirate concentrate (BMAC) source tissues, but current methods to do so were established in cultured cell populations. Given that surface marker and gene expression change in cultured cells, it is doubtful that these strategies are valid to quantify MSCs in fresh BMAC.

Purpose: To establish the presence, quantity, and heterogeneity of BMAC-derived MSCs in minimally manipulated BMAC using currently available strategies. Read More

Cell Oncol (Dordr) 2021 Mar 1. Epub 2021 Mar 1.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Department of Hematology, Xiangya Hospital; Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha, 410078, China.

Purpose: Bone marrow stromal cells (BMSCs) have been implicated in multiple myeloma (MM) progression. However, the underlying mechanisms remain largely elusive. Therefore, we aimed to explore key factors in BMSCs that contribute to MM development. Read More

Elife 2021 Mar 1;10. Epub 2021 Mar 1.

Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, United States.

Osteoarthritis, a highly prevalent degenerative joint disorder, is characterized by joint pain and disability. Available treatments fail to modify osteoarthritis progression and decrease joint pain effectively. Here, we show that intermittent parathyroid hormone (iPTH) attenuates osteoarthritis pain by inhibiting subchondral sensory innervation, subchondral bone deterioration, and articular cartilage degeneration in a destabilized medial meniscus (DMM) mouse model. Read More