Development and validation of the nasopharyngeal cancer scale among the system of quality of life instruments for cancer patients (QLICP-NA V2.0): combined classical test theory and generalizability theory.

Qual Life Res 2016 08 29;25(8):2087-100. Epub 2016 Feb 29.

School of Humanities and Management, Research Center on Quality of Life and Applied Psychology, Guangdong Medical College, Dongguan, 523808, Guangdong, China.

Objectives: This research was designed to develop a nasopharyngeal cancer (NPC) scale based on quality of life (QOL) instruments for cancer patients (QLICP-NA). This scale was developed by using a modular approach and was evaluated by classical test and generalizability theories.

Methods: Programmed decision procedures and theories on instrument development were applied to create QLICP-NA V2.0. A total of 121 NPC inpatients were assessed using QLICP-NA V2.0 to measure their QOL data from hospital admission until discharge. Scale validity, reliability, and responsiveness were evaluated by correlation, factor, parallel, multi-trait scaling, and t test analyses, as well as by generalizability (G) and decision (D) studies of the generalizability theory.

Results: Results of multi-trait scaling, correlation, factor, and parallel analyses indicated that QLICP-NA V2.0 exhibited good construct validity. The significant difference of QOL between the treated and untreated NPC patients indicated a good clinical validity of the questionnaire. The internal consistency (α) and test-retest reliability coefficients (intra-class correlations) of each domain, as well as the overall scale, were all >0.70. Ceiling effects were not found in all domains and most facets, except for common side effects (24.8 %) in the domain of common symptoms and side effects, tumor early symptoms (27.3 %) and therapeutic side effects (23.2 %) in specific domain, whereas floor effects did not exist in each domain/facet. The overall changes in the physical and social domains were significantly different between pre- and post-treatments with a moderate effective size (standard response mean) ranging from 0.21 to 0.27 (p < 0.05), but these changes were not obvious in the other domains, as well as in the overall scale. Scale reliability was further confirmed by G coefficients and index of dependability, with more exact variance components based on generalizability theory.

Conclusions: QLICP-NA V2.0 exhibited reasonable degrees of validity, reliability, and responsiveness. However, this scale must be further improved before it can be used as a practical instrument to evaluate the QOL of NPC patients in China.

Download full-text PDF

Source Listing
August 2016
18 Reads

Publication Analysis

Top Keywords

qlicp-na v20
side effects
patients qlicp-na
cancer patients
instruments cancer
classical test
nasopharyngeal cancer
factor parallel
quality life
multi-trait scaling
correlation factor
difference qol
qol treated
treated untreated
validity difference
construct validity
indicated qlicp-na


(Supplied by CrossRef)

YF Si et al.
Chinese Archives Otolaryngology Head and Neck Surgery 2010

W Deng et al.
Tumor 2012

Y Han et al.
Chinese Nursing Research 2010

MF Gu et al.
Chinese Journal of Cancer Prevention and Treatment 2012

WHO et al.

CH Wan et al.
Health and Quality of Life Outcomes 2014

L Gao et al.
Chinese Journal of Radiation Oncology 2006

NK Aaronson et al.
Journal of the National Cancer Institute 1993

K Bjordal et al.
Europrean Journal of Cancer 2000

J Ringash et al.
Quality of Life Research 2004

EA Weymuller et al.
Archives of Otolaryngology- Head and Neck Surgery 2001

Similar Publications