Search Our Scientific Publications & Authors

Int J Pharm 2022 Jun 23:121951. Epub 2022 Jun 23.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677; Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS 38677, USA. Electronic address:

Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the apparent solubility and, hence, the oral bioavailability of poorly soluble drugs. The process of formulating ASDs is commonly faced with challenges owing to the intrinsic physical and chemical instability of the initial amorphous form and the long-term physical stability of drug formulations. Numerous research publications on hot-melt extrusion (HME) technology have demonstrated that it is the most efficient approach for manufacturing reasonably stable ASDs. Read More

Nanomaterials (Basel) 2022 Jun 10;12(12). Epub 2022 Jun 10.

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka 564-8680, Japan.

Optimizing stabilizers and solvents is crucial for obtaining highly dispersed nanoparticle inks. Generally, nonpolar (hydrophobic) ligand-stabilized nanoparticles show superior dispersibility in nonpolar solvents, whereas polar ligand (hydrophilic)-stabilized nanoparticles exhibit high dispersibility in polar solvents. However, these properties are too qualitative to select optimum stabilizers and solvents for stable nanoparticle inks, and researchers often rely on their experiences. Read More

Nanomaterials (Basel) 2022 Jun 9;12(12). Epub 2022 Jun 9.

Fraunhofer Institute for Microengineering and Microsystems IMM, 55129 Mainz, Germany.

The separation of colloidal nanocrystals from their original synthesis medium is an essential process step towards their application, however, the costs on a preparative scale are still a constraint. A new combination of approaches for the purification of hydrophobic Quantum Dots is presented, resulting in an efficient scalable process in regard to time and solvent consumption, using common laboratory equipment and low-cost materials. The procedure is based on a combination of solvent-induced adhesion and solid phase extraction. Read More

Drug Dev Ind Pharm 2022 Jun 21:1-9. Epub 2022 Jun 21.

Department of Clinical Pharmacy, Faculty of Pharmacy, University of Science and Technology, Irbid, Jordan.

Objective: This study reports new solubility and physicochemical data for ribociclib (RCB) in water and ten organic solvents including "methanol (MeOH), ethanol (EtOH), isopropyl alcohol (IPA), n-butanol (n-BuOH), propylene glycol (PG), polyethylene glycol-400 (PEG-400), acetone, ethyl acetate (EA), Transcutol-HP (THP), and dimethyl sulfoxide (DMSO)" at 293.2-313.2 K and 101. Read More

ACS Omega 2022 Jun 23;7(22):18834-18839. Epub 2022 May 23.

Toyota Central R&D Labs., Inc., 41-1, Yokomichi, Nagakute, Aichi 480-1192, Japan.

Two-dimensional (2D) materials combine the collective advantages of individual building blocks and synergistic properties and have spurred great interest as a new paradigm in materials science. Especially, exfoliation of 2D semiconductive materials into nanosheets is of significance for both fundamental and potential applications. In this report, silicon-germanium (Si-Ge) nanosheets were synthesized by sonication of porous Si-Ge powder. Read More