Regulation of cardiomyocyte autophagy by calcium.

Am J Physiol Endocrinol Metab 2016 Apr 16;310(8):E587-E596. Epub 2016 Feb 16.

Advanced Center for Chronic Disease and Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile;

Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

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http://dx.doi.org/10.1152/ajpendo.00374.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835942PMC
April 2016
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References

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Bradford PG et al.
Mol Pharmacol 1985

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