Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness.

Authors:
Takashi Nomura
Takashi Nomura
Yao Municipal Hospital
Japan
Mayumi Katoh
Mayumi Katoh
Graduate School of Medicine
Japan
Yosuke Yamamoto
Yosuke Yamamoto
Kyoto University
Japan
Yoshiki Miyachi
Yoshiki Miyachi
Kyoto University Graduate School of Medicine
Japan
Kenji Kabashima
Kenji Kabashima
Kyoto University Graduate School of Medicine
Japan

J Dermatol 2016 Aug 15;43(8):919-27. Epub 2016 Feb 15.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that were described in articles published between 1965 and 2013. In total, there were 1171 regimens; 874, 137, 45 and 115 of which were applied to classic, IS/HIV, IS/non-HIV and infancy-associated EPF, respectively. Classic EPF was preferentially treated with oral indomethacin with efficacy of 84% whereas topical steroids were preferred for IS/HIV, IS/non-HIV and infancy-associated EPF with efficacy of 47%, 73% and 82%, respectively. Other regimens such as oral Sairei-to (a Chinese-Japanese herbal medicine), diaminodiphenyl sulfone, cyclosporin and topical tacrolimus were effective for indomethacin-resistant cases. Although the preclusion of direct comparison among cases was one limitation, this study provides a dataset that is applicable to the construction of therapeutic algorithms for EPF.

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http://doi.wiley.com/10.1111/1346-8138.13287
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http://dx.doi.org/10.1111/1346-8138.13287DOI Listing
August 2016
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(Supplied by CrossRef)
Eosinophilic pustular folliculitis
Ofuji et al.
Acta Derm Venereol 1970
Eosinophilic pustular folliculitis
Ofuji et al.
Dermatologica 1987
Atypical clinical appearance of eosinophilic pustular folliculitis of seborrheic areas of the face
Matsumura et al.
Eur J Dermatol 2012

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