Novel Vasoregulatory Aspects of Hereditary Angioedema: the Role of Arginine Vasopressin, Adrenomedullin and Endothelin-1.

Authors:
Erika Kajdacsi
Erika Kajdacsi
Semmelweis University
Dorottya Csuka
Dorottya Csuka
Semmelweis University
Hungary
Lilian Varga
Lilian Varga
Semmelweis University
Hungary
Zoltan Prohaszka
Zoltan Prohaszka
Semmelweis University
Hungary
Henriette Farkas
Henriette Farkas
Semmelweis University
Hungary
Laszlo Cervenak
Laszlo Cervenak
Semmelweis University
Hungary

J Clin Immunol 2016 Feb 12;36(2):160-70. Epub 2016 Feb 12.

3rd Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4., Budapest, H-1125, Hungary.

The elevation of bradykinin (BK) level during attacks of hereditary angioedema due to C1-Inhibitor deficiency (C1-INH-HAE) is well known. We previously demonstrated that endothelin-1 (ET-1) level also increases during C1-INH-HAE attacks. Although BK and ET-1 are both potent vasoactive peptides, the vasoregulatory aspect of the pathomechanism of C1-INH-HAE has not yet been investigated. Hence we studied the levels of vasoactive peptides in controls and in C1-INH-HAE patients, as well as evaluated their changes during C1-INH-HAE attacks. The levels of arginine vasopressin (AVP), adrenomedullin (ADM) and ET-1 were measured in the plasma of 100 C1-INH-HAE patients in inter-attack periods and of 111 control subjects, using BRAHMS Kryptor technologies. In 18 of the 100 C1-INH-HAE patients, the levels of vasoactive peptides were compared in blood samples obtained during attacks, or in inter-attack periods. AVP, ADM and ET-1 levels were similar in inter-attack samples from C1-INH-HAE patients and in the samples of controls, although cardiovascular risk has an effect on the levels of vasoactive peptides in both groups. The levels of all three vasoactive peptides increased during C1-INH-HAE attacks. Moreover, the levels of ET-1 and ADM as well as their changes during attacks were significantly correlated. This study demonstrated that vascular regulation by vasoactive peptides is affected during C1-INH-HAE attacks. Our results suggest that the cooperation of several vasoactive peptides may be necessary to counterbalance the actions of excess BK, and to terminate the attacks. This may reveal a novel pathophysiological aspect of C1-INH-HAE.

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http://dx.doi.org/10.1007/s10875-016-0239-8DOI Listing
February 2016
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References

(Supplied by CrossRef)
Article in Allergy
M Maurer et al.
Allergy 2011
Article in Am J Phys
M Lortie et al.
Am J Phys 1992
Article in Int Immunopharmacol
M Cugno et al.
Int Immunopharmacol 2003
Article in J Allergy Clin Immunol.
E Kajdacsi et al.
J Allergy Clin Immunol. 2014
Article in Regul Pept
T Eto et al.
Regul Pept 2003
Article in Int Angiol
K Kuwasako et al.
Int Angiol 1997
Article in Endocrinology
H Kato et al.
Endocrinology 1997

HK Caldwell et al.
2006
Article in Allergy Asthma Clin Immunol
T Bowen et al.
Allergy Asthma Clin Immunol 2010
Article in J Clin Immunol
J Czucz et al.
J Clin Immunol 2012

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